The Role of Cocaine- and Amphetamine-Regulated Transcript (CART) in Feeding Behavior

What is the function of CART in regulating feeding behavior?

A. Infusion of an antibody to CART decreases feeding.

B. CART is a peptide localized within the area postrema.

C. CART inhibits eating.

D. CART is excitatory for MCH/orexin neurons.

E. CART is the precursor molecule for the synthesis of CCK.

Answer:

The correct statement is: C. CART inhibits eating.

CART (Cocaine- and Amphetamine-Regulated Transcript) is a neuropeptide that plays a crucial role in regulating feeding behavior. When CART is administered centrally, it has been shown to inhibit eating and suppress appetite. This indicates that CART functions as an appetite suppressant, influencing weight regulation and potentially impacting obesity.

While some of the other statements about CART may not be accurate or well-established, the function of CART in inhibiting eating is supported by research and evidence. Understanding the role of CART in feeding behavior can provide valuable insights into how neuropeptides contribute to overall metabolic regulation.